6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.

@article{Weber20016HydroxykynurenicAA,
  title={6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.},
  author={Marco Weber and Dirk Dietrich and I Gr{\"a}sel and Gerd Reuter and Gabriel J. Seifert and Christian Steinh{\"a}user},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 4},
  pages={1108-15}
}
6-Hydroxykynurenic acid (6-HKA), a derivative of kynurenic acid (KYNA) extracted from Ginkgo biloba leaves, was tested for its putative glutamate receptor (GluR) antagonism in comparison to the scaffold substance. The patch-clamp method together with fast-application techniques were used to estimate inhibition by 6-HKA and KYNA of agonist binding at NMDA and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (NMDARs and AMPARs) of CA1 pyramidal neurones. 6… CONTINUE READING