6-Hydroxycleroda-3,13-dien-15,16-olide protects neuronal cells from lipopolysaccharide-induced neurotoxicity through the inhibition of microglia-mediated inflammation.

@article{Shih20106Hydroxycleroda313dien1516olidePN,
  title={6-Hydroxycleroda-3,13-dien-15,16-olide protects neuronal cells from lipopolysaccharide-induced neurotoxicity through the inhibition of microglia-mediated inflammation.},
  author={Yu-Tzu Shih and Ya-Yun Hsu and F. -H. Chang and Yang-Chang Wu and Y C Lo},
  journal={Planta medica},
  year={2010},
  volume={76 2},
  pages={120-7}
}
Polyalthia longifolia var. pendula is used as an antipyretic agent in indigenous systems of medicine. Microglia-mediated inflammation plays an important role in the pathway leading to neuronal cell death in a number of neurodegenerative diseases. The aim of this study was to investigate the effects of 6-hydroxycleroda-3,13-dien-15,16-olide (PL3) extracted from Polyalthia longifolia var. pendula on lipopolysaccharide(LPS)-induced inflammation in microglia-like HAPI cells and primary microglia… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS