6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition

@inproceedings{Kim20156GingerolRP,
  title={6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition},
  author={Han-Shin Kim and Sang-Hoon Lee and Youngjoo Byun and Hee-Deung Park},
  booktitle={Scientific reports},
  year={2015}
}
Pseudomonas aeruginosa is a well-known pathogenic bacterium that forms biofilms and produces virulence factors via quorum sensing (QS). Interfering with normal QS interactions between signal molecules and their cognate receptors is a developing strategy for attenuating its virulence. Here we tested the hypothesis that 6-gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. In silico studies demonstrated… CONTINUE READING