6-Fluorocatecholamines as false adrenergic neurotransmitters.

  title={6-Fluorocatecholamines as false adrenergic neurotransmitters.},
  author={Chuang Chin Chiueh and Zofia Zukowska-Gr{\'o}jec and Kenneth Lee Kirk and Irwin J. Kopin},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={225 3},
In the present study 6-fluoronorepinephrine (6F-NE) is shown to be formed from 6-fluorodopamine (6F-DA) in vivo. The beta-hydroxylated fluorocompound is taken up by and stored in the adrenergic nerve terminals and can be released during sympathetic nerve stimulation. In the heart, the turnover rate of the exogenously administered 6F-NE was about the same as that of tritium-labeled norepinephrine. In the central nervous system, 6F-DA can be taken up by the nigrostriatal neurons. After… CONTINUE READING


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