6-Epicastanospermine, a novel indolizidine alkaloid that inhibits alpha-glucosidase.

  title={6-Epicastanospermine, a novel indolizidine alkaloid that inhibits alpha-glucosidase.},
  author={Russell J Molyneux and James N. Roitman and G Dunnheim and T Szumilo and Alan D Elbein},
  journal={Archives of biochemistry and biophysics},
  volume={251 2},
A second indolizidine alkaloid, epimeric with castanospermine, has been isolated from seeds of the Australian tree Castanospermum australe. The structure was established as 6-epicastanospermine by proton and carbon-13 nuclear magnetic resonance spectroscopy and mass spectrometry. 6-Epicastanospermine was found to be a potent inhibitor of amyloglucosidase, (an exo-1,4-alpha-glucosidase), a weak inhibitor of beta-galactosidase, and not to inhibit beta-glucosidase and alpha-mannosidase. These… CONTINUE READING