6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo.

@article{Oliveira20156DimethylaminopurineAC,
  title={6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo.},
  author={Rodrigo Juliano Oliveira and M. S. Mantovani and J R Pesarini and M O Mauro and A. F. da Silva and Tamires T. Souza and L R Ribeiro},
  journal={Genetics and molecular research : GMR},
  year={2015},
  volume={14 1},
  pages={834-49}
}
The compounds 6-dimethylaminopurine (6-DMAP) and cyclohexamide (CHX) are currently used to stimulate the development of embryos produced by nuclear transfer in the production of cloned mammals with a great deal success. This study investigated the effects of 6-DMAP and CHX in vivo using biological assays to evaluate reproductive performance in females, teratogenesis, and mutagenesis. The results of this study demonstrated that the activating agents of oocyte cytoplasm, 6-DMAP and CHX, altered… CONTINUE READING