6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7

@article{Campbell19986CkineA,
  title={6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7 },
  author={James J Campbell and Edward P. Bowman and Kristine Murphy and Kenneth R. Youngman and Michael A. Siani and Darren A Thompson and Lijun Wu and Albert Zlotnik and Eugene C. Butcher},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={1053 - 1059}
}
The beta chemokine known as 6-C-kine, secondary lymphoid-tissue chemokine (SLC), TCA4, or Exodus-2 (herein referred to as 6CK/SLC) can trigger rapid integrin-dependent arrest of lymphocytes rolling under physiological shear and is highly expressed by high endothelial venules, specialized vessels involved in lymphocyte homing from the blood into lymph nodes and Peyer's patches. We show that 6CK/SLC is an agonist for the lymphocyte chemoattractant receptor, CCR7 (EBI-1, BLR-2), previously… CONTINUE READING
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lecular mechanisms of lymphocyte homing to peripheral lymph nodes

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