6-Bromoindirubin-3′-oxime (BIO) induces proliferation of human mesenchymal stem cells (hMSCs)

@article{Hoffman20116Bromoindirubin3oximeI,
  title={6-Bromoindirubin-3′-oxime (BIO) induces proliferation of human mesenchymal stem cells (hMSCs)},
  author={M. D. Hoffman and Masahiko Takahata and D.S.M. Benoit},
  journal={2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC)},
  year={2011},
  pages={1-2}
}
The process of bone healing is a highly orchestrated process involving mesenchymal progenitor cells (e.g., periosteal stem cells). The cascade begins with recruitment and robust proliferation of these cells followed by differentiation to osteogenic and chondrogenic cell types, which produce matrix that eventually becomes mineralized. Thus, promoting… CONTINUE READING