6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

@article{Rais20056BenzylthioinosineAA,
  title={6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.},
  author={Reem H. Rais and Omar N Al Safarjalani and Vikas Yadav and Vincenzo Guarcello and Marion C. Kirk and Chung K Chu and Fardos N. M. Naguib and Mahmoud H El Kouni},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 10},
  pages={1409-19}
}
Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any other enzyme of the purine salvage in T. gondii and has been established as a potential chemotherapeutic target for the treatment of toxoplasmosis. Certain 6-substituted purine nucleosides act as subversive substrates of T. gondii, but not the human, adenosine kinase. Therefore, these compounds are preferentially metabolized to their… CONTINUE READING