6-Alkynyl- and 6-aryl-substituted (R)-pipecolic acid derivatives.

@article{Sadiq20136AlkynylA6,
  title={6-Alkynyl- and 6-aryl-substituted (R)-pipecolic acid derivatives.},
  author={A. Sadiq and N. Sewald},
  journal={Organic letters},
  year={2013},
  volume={15 11},
  pages={
          2720-2
        }
}
(R)-α-Aminoadipic acid is a readily available enantiomerically pure starting material for the synthesis of (R)-pipecolic acid and its derivatives. Sonogashira or Suzuki cross-coupling reactions of an N-formyl pipecolate-derived vinyl bromide furnish 6-alkynyl or aryl derivatives. Reduction with sodium cyanoborohydride and subsequent N-deformylation provide 6-alkynyl substituted (R)-pipecolic acid derivatives, valuable building blocks for amino acid and peptide chemistry. 
(R)-α-Aminoadipic Acid: A Versatile Precursor for the Synthesis of D-Amino Acids
Electrophoretic deposition polymerization of diacetylenes with tunable structure.
The Sonogashira Reaction

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