6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents.

@article{Lin20066Acyl4arylalkyl57dihydroxycoumarinsAA,
  title={6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents.},
  author={Chun Mao Lin and Sheng-Tung Huang and Fu-Wei Lee and Hsien-Saw Kuo and Mei Hsiang Lin},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 13},
  pages={
          4402-9
        }
}
A series of coumarin derivatives were synthesized in two steps from phloroglucinol. The anti-inflammatory activities of these derivatives were evaluated by means of inhibiting NO production in LPS-induced RAW 264.7 cells. Derivatives 3, 8, 10, 11, and 13 exhibited low micromolar levels of anti-inflammatory activities, and these derivatives also protected DNA against hydroxyl radical attack. Coumarin derivative 8 was the most potent derivative among those tested herein against NO production in… CONTINUE READING
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