6 Å-Resolution X-ray structure of a variable surface glycoprotein from Trypanosoma brucei

The variable surface glycoprotein (VSG) is the predominant component of the surface coat of the African trypanosome1. The expression of antigenically distinct VSGs on minor populations during infection allows the parasite to escape the host immune response2,3. Purification of the protein is facilitated by the enzymatic release of a soluble form of VSG (sVSG… (More)