6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.

  title={6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.},
  author={Anton{\'i}n Hol{\'y} and Ivan Votruba and Milena Masoj{\'i}dkov{\'a} and Graciella Andrei and Robert Snoeck and Lieve M J Naesens and Eric De Clercq and Jan Balzarini},
  journal={Journal of medicinal chemistry},
  volume={45 9},
6-Hydroxypyrimidines substituted at positions 2 and 4 by hydrogen, methyl, amino, cyclopropylamino, dimethylamino, methylsulfanyl, or hydroxyl group afford by the reaction with diisopropyl 2-(chloroethoxy)methylphosphonate in the presence of NaH, Cs(2)CO(3), or DBU a mixture of N(1)- and O(6)-[2-(diisopropylphosphorylmethoxy)ethyl] isomers which were converted to the free phosphonic acids by treatment with bromotrimethylsilane followed by hydrolysis. Analogously, 2,4-diamino-6-hydroxypyrimidine… CONTINUE READING