6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

@article{Yang201261naphthylmethylsulfanyl9HpurineIG,
  title={6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.},
  author={Xiaoguang Yang and Yong-Li Bao and Yan-Xin Huang and Lu-guo Sun and Yuwei Zhang and Chun-lei Yu and Yin Wu and Yuxin Li},
  journal={European journal of pharmacology},
  year={2012},
  volume={695 1-3},
  pages={27-33}
}
Due to the increasing incidence of cancer, a leading cause of death worldwide, discovery of new therapeutic drugs is urgently needed. By screening for agents with low toxicity that selectively target cancer cells, we found that 6-[(1-naphthylmethyl) sulfanyl]-9H-purine (NMMP), a derivative of 6-mercaptopurine (6-MP), could reduce the viability of five human cancer cell lines. Further study suggested that NMMP inhibition of the proliferation of hepatocellular carcinoma (HepG2) cells was… CONTINUE READING

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