6′-O-Caffeoylarbutin inhibits melanogenesis in zebrafish

  title={6′-O-Caffeoylarbutin inhibits melanogenesis in zebrafish},
  author={Min Xu and Qiaocong Lao and Ping Zhao and Xiao-yu Zhu and Hong-Tao Zhu and Xulu Luo and Chong-ren Yang and Jian-Hui He and Chun-Qi Li and Ying-Jun Zhang},
  journal={Natural Product Research},
  pages={932 - 934}
6′-O-Caffeoylarbutin, an arbutin derivative, is a naturally occurring glucoside of hydroquinone from Vaccinium dunalianum. On anti-melanogenic effect assay, 6′-O-caffeoylarbutin expressed a stronger anti-melanin activity in a dose-dependent manner with about a two-fold more than that of arbutin, but with less toxicity about a two-fold lower than that of arbutin. In addition, melanin synthesis could be fully recovered after the removal of 6′-O-caffeoylarbutin. The result suggested that 6′-O… 

Effective enzymatic caffeoylation of natural glucopyranosides.

A new arbutin derivative from the leaves of Vaccinium dunalianum wight

The structure of 1 was elucidated by extensive 1D and 2D NMR, HR-MS and CD spectroscopic analyses and, kaempferol 3-O-β-D-sambubioside (7) was isolated from the genus Vaccinium for the first time.

HPLC simultaneous determination of arbutin, chlorogenic acid and 6′-O-caffeoylarbutin in different parts of Vaccinium dunalianum Wight

A reliable, reproducible and accurate method for simultaneous and quantitative determination of 1–3 is developed by RP-HPLC analysis and this method should be appropriate for the quality assurance of unprocessed and processed materials of V. dunalianum.

De novo transcriptome sequencing of Vaccinium dunalianum Wight to investigate arbutin and 6'-O-caffeoylarbutin synthesis

Investigation of potential pathways associated with arbutin synthesis and potential synthetic routes to 6′-O-caffeoylarbutin (CA) in Vaccinium dunalianum Wight (Ericaceae) via de novo transcriptome sequencing found some enzymes in pathways related to glycometabolism and tyrosine metabolism may participate in CA synthesis.

Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models.

Data reveal that Closantel has antiangiogenesis and anticancer effects and could be a potential drug candidate for animal and human cancer treatments.

Significantly Enhanced Synthesis of Aromatic Esters of Arbutin Catalyzed by Immobilized Lipase in Co-solvent Systems

Highly efficient and regioselective synthesis of pharmacologically interesting aromatic esters of arbutin catalyzed by immobilized lipase from Penicillium expansum in co-solvent systems was

Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway

Results suggest that inhibition of VEGF signaling at its receptor level and downstream pathways may likely be responsible for the antiangiogenic activity of Ponatinib.

Selection of appropriate reference genes in different tissues of Vaccinium dunalianum Wight by quantitative real-time PCR for gene expression studies

Abstract: Quantitative real-time polymerase chain reaction (PCR) is a powerful tool for investigating relevant changes in gene expression. At present, there are no reports on reference genes for

Diversity of endophytic fungi from the leaves of Vaccinium dunalianum

A high diversity of endophytic fungi from V. dunalianum leaves was observed with high species richness S, but a low dominant index λ, which indicates that the strains P. capitalensis and G. mangiferae with potential antimicrobial activity were the dominant endophytes to the sampling of leaves.



Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent.

dA facilitated fading of pre-tanned skin to a statistically significant greater extent than either HQ or no treatment, demonstrating that dA is a potentially safe, effective, and reversible tyrosinase inhibitor.

DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency

It is demonstrated that dA has potential tyrosinase inhibitory activity that can result in skin lightening and may be used to ameliorate hyperpigmentary lesions.

Identification of anti-melanogenic natural compounds from Galega officinalis and further drug repositioning.

The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register.

  • J. Levitt
  • Medicine
    Journal of the American Academy of Dermatology
  • 2007

The safety of hydroquinone

Despite 40–50 years use of hydroquinone for medical conditions, there has not been a single documented case of either a cutaneous or internal malignancy associated with this drug.

Comparative efficacy and safety

  • skin lightening potency. Exp Dermatol
  • 2006