6′-O-Caffeoylarbutin inhibits melanogenesis in zebrafish

@article{Xu20146OCaffeoylarbutinIM,
  title={6′-O-Caffeoylarbutin inhibits melanogenesis in zebrafish},
  author={Min Xu and Qiaocong Lao and Ping Zhao and Xiao-yu Zhu and Hong-Tao Zhu and Xulu Luo and Chong-ren Yang and Jian-Hui He and Chun-Qi Li and Ying-Jun Zhang},
  journal={Natural Product Research},
  year={2014},
  volume={28},
  pages={932 - 934}
}
6′-O-Caffeoylarbutin, an arbutin derivative, is a naturally occurring glucoside of hydroquinone from Vaccinium dunalianum. On anti-melanogenic effect assay, 6′-O-caffeoylarbutin expressed a stronger anti-melanin activity in a dose-dependent manner with about a two-fold more than that of arbutin, but with less toxicity about a two-fold lower than that of arbutin. In addition, melanin synthesis could be fully recovered after the removal of 6′-O-caffeoylarbutin. The result suggested that 6′-O… 

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