6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents.

Abstract

Structurally unique 6,7-seco-ent-kaurenes, which are widely distributed in the genus Isodon, have attracted considerable attention because of their antitumor activities. Previously, a convenient conversion of commercially available oridonin (1) to 6,7-seco-ent-kaurenes was developed. Herein, several novel spiro-lactone-type ent-kaurene derivatives bearing… (More)
DOI: 10.1021/acs.jnatprod.7b00057

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