5HT3 receptor antagonist (ondansetron) reverses depressive behavior evoked by chronic unpredictable stress in mice: modulation of hypothalamic-pituitary-adrenocortical and brain serotonergic system.

@article{Gupta20145HT3RA,
  title={5HT3 receptor antagonist (ondansetron) reverses depressive behavior evoked by chronic unpredictable stress in mice: modulation of hypothalamic-pituitary-adrenocortical and brain serotonergic system.},
  author={Deepali Gupta and Mahesh Radhakrishnan and Yeshwant Vijay Kurhe},
  journal={Pharmacology, biochemistry, and behavior},
  year={2014},
  volume={124},
  pages={129-36}
}
Chronic stress is one of the major causes of depression, associated with behavioral and biochemical impairments. 5HT3 receptor antagonists (such as ondansetron) have shown alleviation of depressive symptomology in preclinical and in few clinical studies. However, their effects in chronic stress-induced depressive behavior and the underlying mechanism(s) are… CONTINUE READING