53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

@inproceedings{Bouwman201053BP1LR,
  title={53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers},
  author={Peter Bouwman and A. E. B. Aly and Jose Miguel Escandell and Mark Pieterse and Jiřina B{\'a}rtkov{\'a} and Hanneke van der Gulden and Sanne Hiddingh and Maria N. Thanasoula and Atul B. Kulkarni and Qifeng Yang and Bruce G. Haffty and Johanna Tommiska and Carl Blomqvist and Ronny Drapkin and Donald J. Adams and Heli Nevanlinna and Jiri Bartek and Madalena Tarsounas and Shridar Ganesan and Jos Jonkers},
  booktitle={Nature Structural &Molecular Biology},
  year={2010}
}
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of 53BP1 abrogates the ATM-dependent checkpoint response and G2 cell-cycle arrest triggered by the accumulation of DNA breaks in… CONTINUE READING
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