53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

@article{Lottersberger201553BP1AT,
  title={53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair},
  author={Francisca Lottersberger and Roos Anna Karssemeijer and Nadya Dimitrova and Titia de Lange},
  journal={Cell},
  year={2015},
  volume={163},
  pages={880-893}
}
Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair remain unclear. Here, we use a telomere-based system to track DNA damage foci with high resolution in living cells. We find that the greater mobility of damaged chromatin requires 53BP1, SUN1/2 in the linker of the nucleoskeleton, and cytoskeleton (LINC) complex and dynamic microtubules. The data further demonstrate… CONTINUE READING
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A cell cycle - dependent regulatory circuit composed of 53 BP 1 - RIF 1 and BRCA 1 - CtIP controls DNA repair pathway choice

  • C. Escribano-Dı́az, A. Orthwein, +6 authors M. D. Canny
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