535 Tumor targeting and tissue distribution of solitomab (AMG 110; anti-EpCAM BiTE®) in human EpCAM-positive tumor bearing mice

@article{Warnders2014535TT,
  title={535 Tumor targeting and tissue distribution of solitomab (AMG 110; anti-EpCAM BiTE{\textregistered}) in human EpCAM-positive tumor bearing mice},
  author={Frank-Jan Warnders and Stijn J.H. Waaijer and Marjolijn N. Lub-de Hooge and Matthias Friedrich and Anton G. T. Terwisscha van Scheltinga and Petra Deegen and Sabine Stienen and Peter C Pieslor and Hung-kam Cheung and Jos G. W. Kosterink and Ege de Vries},
  journal={European Journal of Cancer},
  year={2014},
  volume={50},
  pages={174}
}
1 Citations

Harnessing T cells to fight cancer with BiTE® antibody constructs – past developments and future directions

TLDR
Pertinent questions comprise how to maximize BiTE® penetration and T‐cell infiltration of the tumor while simultaneously minimizing any adverse events, which is currently explored by a continuous intravenous infusion approach.