50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams

  title={50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams},
  author={Gayle M. Halford and Marie Lordkipanidz{\'e} and Steve P. Watson},
  pages={415 - 422}
2011 marks the 50th anniversary of the discovery of ibuprofen. This article is a focus on the personal reflections and career of Dr Stewart Adams OBE, the scientist whose research lead to the discovery of the cyclooxygenase inhibitor. When Dr Adams discovered ibuprofen, he was working as a pharmacologist in the Research Department for the Boots Pure Drug Company Ltd. Dr Adams was assigned to work on rheumatoid arthritis (RA) and chose in 1953 to search for a drug that would be effective in RA… 

Ibuprofen in the current practice of the pharmacist in the community pharmacy

Some legal aspects that are linked to the pharmacist competences, and also its approach regarding IBU recommendation during pregnancy and breastfeeding and also to children and to a category of patients who have various associated pathologies are mentioned.

Understanding the significance and outcomes of clinical pharmacology of ibuprofen

The actual pharmacological effects, therapeutic uses and side effects of ibuprofen, drug communication, and food-drug collaboration that have been considered over the last decade are summarized.

Injectable Nonsteroidal Anti-Inflammatory Drugs in Sport

  • M. Matava
  • Medicine
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
  • 2018
Injectable ketorolac is an effective analgesic and anti-inflammatory drug, however, its potential effectiveness must be weighed against the risk of potential complications in all athletes, especially those who participate in contact/collision sports.

A Comprehensive Spectroscopic Analysis of the Ibuprofen Binding with Human Serum Albumin, Part I

A significant effect of temperature and pH of the human serum albumin solution on the strength and type of interaction of ibuprofen with HSA is shown.

Pharmacological Evaluation of Marginally Designed New Profen Analogues

The synthesized hydrazide analogues have highly significant pharmacological activities and have the potential to be further explored as new drug molecules.

Simultaneous Determination of Methocarbamol and Ibuprofen in the Presence of Five Related Impurities by Reversed Phase Liquid Chromatography

Abstract Methocarbamol (MET) and ibuprofen (IBU) in combination are available in market by brand name Robax Platinum® which is a combined medication for the effective relief of pain associated with

Drug repurposing to improve treatment of rheumatic autoimmune inflammatory diseases

The past century has been characterized by intensive efforts to introduce new treatments to individuals with rheumatic autoimmune inflammatory diseases (RAIDs), often by ‘borrowing’ treatments already employed in one RAID or previously used in an entirely different disease, a concept known as drug repurposing.


The anti-inflammatory and analgesic tests revealed that both marginal and dimerized analogues exhibited highly significant activities in experimental animals in a dose dependent manner, and new COX inhibitor(s) with optimized potency, efficacy against inflammatory conditions were explored.



The Propionic Acids: A Personal Perspective

  • S. Adams
  • Medicine
    Journal of clinical pharmacology
  • 1992
Ibuprofen proved to be effective as a prescription drug in a range of painful nonrheumatic conditions and on the basis of its good safety record was approved as an OTC analgesic in 1983 in the United Kingdom and in 1984 in the USA.

Ibuprofen: pharmacology, efficacy and safety

Paediatric use of ibuprofen is reviewed and the main results are that the drug is relatively safe and effective as a treatment of acute pain and fever, and is probably more effective than paracetamol as an antipyretic.

Ibuprofen, the propionics and NSAIDs: Personal reflections over four decades

In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division

Ibuprofen: A Journey from Prescription to Over-the-Counter Use

  • N. Moore
  • Medicine
    Journal of the Royal Society of Medicine
  • 2007
The safety of OTC or non-prescription use of ibuprofen is distinguished from its prescription use because it is associated with the least risk of GI complications compared with other NSAIDs and is considered relatively benign in overdose.

Penicillin: its discovery and early development.

  • B. Ligon
  • Medicine
    Seminars in pediatric infectious diseases
  • 2004
The discovery and development of penicillin represent one of the most important developments in the annals of medical history and presents a brief overview of the events that occurred in the progress from discovery to implementation as a therapeutic agent.

The effect of ibuprofen on platelet function in vivo.

  • Y. Ikeda
  • Medicine, Biology
    The Keio journal of medicine
  • 1977
The results may suggest that Ibuprofen is responsible for easy bruises in its users and the mechanism by which induces the platelet dys-function is somewhat different from that by aspirin.

The metabolism of ibuprofen.

After oral administration ibuprofen appeared mainly in unchanged form in the plasma of rats, dogs, baboons and men, and was strongly bound to plasma protein in vitro, 95% being bound in baboon, 96% in rat, and 94% in dog plasma.

Use of ibuprofen and risk of Parkinson disease

The association between use of ibuprofen and lower PD risks, not shared by other NSAIDs or acetaminophen, suggests ib uprofen should be further investigated as a potential neuroprotective agent against PD.

Effect of ibuprofen on platelet function in normal subjects and hemophiliac patients

The results suggest that ibuprofen may be given to hemophiliac subjects with greater safety than some of the older anti‐inflammatory drugs.

Ibuprofen Protects Platelet Cyclooxygenase from Irreversible Inhibition by Aspirin

The findings indicate that ibuprofen-like indomethacin and other nonsteroidal antiinf lammatory drugs react with the heme group of cyclooxygenase to prevent arachidonic acid conversion.