500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.

@article{Hynynen2004500elementUP,
  title={500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.},
  author={Kullervo Hynynen and Gregory T. Clement and Nathan McDannold and Natalia Vykhodtseva and Randy L King and Phillip Jason White and Shuki Vitek and Ferenc A. Jolesz},
  journal={Magnetic resonance in medicine},
  year={2004},
  volume={52 1},
  pages={100-7}
}
The aim of this study was to test a prototype MRI-compatible focused ultrasound phased array system for trans-skull brain tissue ablation. Rabbit thigh muscle and brain were sonicated with a prototype, hemispherical 500-element ultrasound phased array operating at frequencies of 700-800 kHz. An ex vivo human skull sample was placed between the array and the animal tissue. The temperature elevation during 20-30-sec sonications was monitored using MRI thermometry. The induced focal lesions were… CONTINUE READING

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