5-y Follow-up Study of Patients with Neuroborreliosis

@article{Berglund20025yFS,
  title={5-y Follow-up Study of Patients with Neuroborreliosis},
  author={Johan Berglund and Louise Stjernberg and Katharina Ornstein and Katarina Tykesson-Joelsson and Hallstein Walter},
  journal={Scandinavian Journal of Infectious Diseases},
  year={2002},
  volume={34},
  pages={421 - 425}
}
The objective of this follow-up study was to determine the long-term outcome of strictly classified cases of neuroborreliosis treated with antibiotics. A 1-y prospective population-based survey of Lyme borreliosis was conducted in southern Sweden between 1992 and 1993. A total of 349 identified cases with suspected neuroborreliosis were followed up 5 y later. Medical records were reviewed and all participants filled in a questionnaire. Of those patients classified with definite neuroborreliosis… 

Long-term Clinical Outcome After Lyme Neuroborreliosis in Childhood

TLDR
The long-term clinical recovery rate was 73% and nonspecific subjective symptoms such as headache, fatigue, or memory or concentration problems were reported as often among patients as controls and should not be considered as sequelae after LNB.

Prognose pädiatrischer Patienten nach Neuroborreliose

TLDR
The prognosis of neuroborreliosis in childhood in central europe after early and adequate therapy to be very favorable.

Characteristics and Clinical Outcome of Lyme Neuroborreliosis in a High Endemic Area, 1995-2014: A Retrospective Cohort Study in Denmark.

TLDR
The findings disprove that all patients with LNB develop positive serum Borrelia antibodies within 6 weeks after infection and highlight the need for standardized diagnostic routines and a better follow-up for LNB patients.

Lyme Neuroborreliosis in Children: A Prospective Study of Clinical features, Prognosis, and Outcome

TLDR
Clinical recovery was satisfactory in children being evaluated for NB although persistent symptoms from facial nerve palsy occurred, and persistent headache and fatigue at follow-up should be considered as attributable to NB.

Neuroborreliosis--an epidemiological, clinical and healthcare cost study from an endemic area in the south-east of Sweden.

TLDR
CSF analysis is necessary for the diagnosis of NB, because some patients develop antibodies in serum later than in CSF, and early diagnosis of borreliosis would result in reduced human suffering and in economic gain.

Clinical presentation of childhood neuroborreliosis; neurological examination may be normal

TLDR
In this study, 79% of paediatric neuroborreliosis patients presented with neurological signs, most often facial nerve palsy, and 21% presented in an atypical way without neurological signs.

Acute facial palsy in children--a 2-year follow-up study with focus on Lyme neuroborreliosis.

European neuroborreliosis: Long term follow-up

TLDR
The aim was to assess the long-term impact of LNB on Health Related Quality of Life (HRQoL) in a controlled study of well-characterized adult European LNB patients, and to compare the neuropsychological (NP) functioning by assessing executive/attention functions, processing speed and memory in a group of adult L NB patients 30 months after treatment to a matched control group.

Intravenous ceftriaxone compared with oral doxycycline for the treatment of Lyme neuroborreliosis

TLDR
Intravenous ceftriaxone or oral doxycycline was found to be effective, safe, and convenient for treatment of Lyme neuroborreliosis.

Lyme Neuroborreliosis.

TLDR
Lyme neuroborreliosis has a favorable prognosis if treated early and its efficacy is equivalent to that of intravenously administered beta-lactam antibiotics (penicillin G, ceftriaxone, and cefotaxime).
...

References

SHOWING 1-10 OF 18 REFERENCES

Paediatric facial paralysis caused by Lyme borreliosis: a prospective and retrospective analysis.

TLDR
It is indicated that Lyme borreliosis is a frequent cause of acute paediatric FP in an endemic area and suggests that FP caused by LB in children has a favourable prognosis, even when left untreated.

Follow-up of patients treated with oral doxycycline for Lyme neuroborreliosis.

TLDR
Oral doxycycline seems to be an effective, convenient and inexpensive alternative for the treatment of Lyme neuroborreliosis.

Evaluation of study patients with Lyme disease, 10-20-year follow-up.

TLDR
The overall current health status of each patient group was good, but sequelae were apparent primarily among patients with facial palsy who did not receive antibiotics for acute neuroborreliosis.

Variable CSF findings in early and late Lyme neuroborreliosis: A follow-up study in 47 patients

  • R. Kaiser
  • Medicine, Biology
    Journal of Neurology
  • 2004
TLDR
Clinical recovery was usually accompanied by a considerable improvement of the blood-CSF barrier function and pleocytosis, and six months after antibiotic treatment, patients with ELN still revealed evidence of intrathecal synthesis of total IgM, whereas those with LLN did not.

Lyme borreliosis — an overdiagnosed disease?

TLDR
It is concluded that there probably is an overdiagnosis of Lyme borreliosis and that better microbiological methods are needed to confirm active disease.

Serological follow-up after treatment of patients with erythema migrans and neuroborreliosis

TLDR
Investigation of the duration and kinetics of immunoglobulin M (IgM) and IgG antibodies against Borrelia burgdorferi in serum after treatment of Lyme borreliosis showed that patients with erythema migrans and early neuroborreliosis more often initially had highly elevated IgM optical density (OD) values and low IgG OD values against B. burgdorffi, while the opposite was found in patients with late neurobor Reliosis.

Neurological and psychological symptoms after the severe acute neuroborreliosis.

TLDR
The results of this study suggest the existence of long-lasting consequences of acute neuroborreliosis, which can significantly influence the quality of life of patients.

Clinical and serologic follow-up in patients with neuroborreliosis

TLDR
Although neurologic deficits decreased significantly, more than half of patients with clinical signs of neuroborreliosis had unspecific complaints resembling a chronic fatigue syndrome and showed persisting positive immunoglobulin M serum titers for Borrelia in the Western blot analysis.

Lyme meningitis: a one-year follow up controlled study.

TLDR
It is revealed that Lyme meningitis frequently occurs without meningeal signs and is often accompanied by additional neurological and/or other manifestations of Lyme borreliosis.

The Long-Term Clinical Outcomes of Lyme Disease: A Population-Based Retrospective Cohort Study

TLDR
The prevalence of persistent symptoms in unselected patients with a history of Lyme disease was ascertained; their rheumatologic, neurologic, and health status outcomes were determined; and potential risk factors for these long-term sequelae were identified.