5'-methylaristeromycin and related derivatives.


The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes the facile stereospecific synthesis, where necessary, of such C-5'-methylated aristeromycin derivatives.

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@article{Ye20065methylaristeromycinAR, title={5'-methylaristeromycin and related derivatives.}, author={Wei Ye and Stewart W. Schneller}, journal={The Journal of organic chemistry}, year={2006}, volume={71 22}, pages={8641-3} }