5-methoxy-N,N-dimethyltryptamine: An ego-dissolving endogenous neurochemical catalyst of creativity

  title={5-methoxy-N,N-dimethyltryptamine: An ego-dissolving endogenous neurochemical catalyst of creativity},
  author={Christoph Germann},
  • C. Germann
  • Published 16 March 2019
  • Psychology, Biology
  • bioRxiv
5-Methoxy-N,N-dimethyltryptamine (acronymized as 5-MeO-DMT) is sui generis among the numerous naturally-occurring psychoactive substances due to its unparalleled ego-dissolving effects which can culminate in a state of nondual consciousness (which is phenomenologically similar to transformative peak experiences described in various ancient contemplative traditions, e.g., Advaita Vedānta, Mahāyāna Buddhism). The enigmatic molecule is endogenous to the human brain and has profound psychological… 
Effectiveness of Psilocybin on Depression: A Qualitative Study
Introduction: Psilocybin mushroom use is well documented in spiritual and religious ceremonies globally. This drug is now the most popular in Europe and the USA. Objective: The objective of this


Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT).
The synthesis of DMT is covered, as well as its pharmacology, metabolism, adverse effects, and potential use in medicine.
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs.
The observed cortical alterations are related to the psychotomimetic action of 5-MeO-DMT, and the present model may help to understand the neurobiological basis of hallucinations and to identify new targets in antipsychotic drug development.
Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many
Neuropharmacology of N,N-dimethyltryptamine
Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryptamine
In silico systems biology analyses support 5-MeO-DMT’s anti-inflammatory effects and reveal a modulation of proteins associated with the formation of dendritic spines, including proteins involved in cellular protrusion formation, microtubule dynamics and cytoskeletal reorganization.
Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution
The Effects of Hallucinogens on Gene Expression.
What is currently known about the molecular genetic responses to psychedelics within the brain is summarized and how gene expression changes may contribute to altered cellular physiology and behaviors is discussed.
Identity of a New World Psychoactive Toad
These experiments are the first documentation of a hallucinogenic agent from the animal kingdom and provide clear evidence of a psychoactive toad that could have been employed by Precolumbiae peoples of the New World.