5-hydroxytryptophol in human cerebrospinal fluid: conjugation, concentration gradient, relationship to 5-hydroxyindoleacetic acid, and influence of hereditary factors.

@article{Beck19845hydroxytryptopholIH,
  title={5-hydroxytryptophol in human cerebrospinal fluid: conjugation, concentration gradient, relationship to 5-hydroxyindoleacetic acid, and influence of hereditary factors.},
  author={O. A. Beck and Stefan Borg and Gunnar Edman and Bengt Fyr{\"o} and Gabriella Oxenstierna and G{\"o}ran Sedvall},
  journal={Journal of neurochemistry},
  year={1984},
  volume={43 1},
  pages={58-61}
}
The serotonin metabolite 5-hydroxytryptophol was studied in human cerebrospinal fluid. A minor fraction (approximately 13%) was found in conjugated form from which it was liberated by treatment with sulphatase containing beta-glucuronidase activity. A concentration gradient of 5-hydroxytryptophol concentration was shown on lumbar tapping and the concentration in ventricular CSF was about 2.5 times higher than that in lumbar CSF. 5-Hydroxytryptophol and 5-hydroxyindoleacetic acid concentrations… CONTINUE READING

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