5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala.

@article{Sugita19925hydroxytryptamineIA,
  title={5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala.},
  author={Shio Sugita and K Z Shen and R Alan North},
  journal={Neuron},
  year={1992},
  volume={8 1},
  pages={199-203}
}
A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino… CONTINUE READING