5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

@article{Sugita19925hydroxytryptamineIA,
  title={5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala},
  author={Shunsuke Sugita and K Z Shen and R. Alan North},
  journal={Neuron},
  year={1992},
  volume={8},
  pages={199-203}
}
5-HT3 receptors
Neuropharmacology of 5-HT3 Receptor Ligands
TLDR
The present chapter reviews the beginnings of a pharmacological understanding of this receptor and the therapeutic implications of drugs which have affinity for it.
A slow excitatory postsynaptic potential mediated by 5-HT2 receptors in nucleus prepositus hypoglossi
  • D. Bobker
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
Recordings of neurons of the nucleus prepositus hypoglossi in slices of guinea pig medulla indicate that the s-EPSP is mediated by 5-HT acting upon5-HT2 receptors, providing strong support for the role of 5- HT as an excitatory neurotransmitter in the CNS.
The 5-HT3 Receptor Channel: Function, Activation and Regulation
TLDR
The activation of the 5-HT3R opens a cationic ion channel that depolarizes the membrane, thereby activating a rapid excitatory response in a variety of central and peripheral nervous system (CNS and PNS) preparations.
5-HT3 Receptors*
  • S. Lummis
  • Biology, Chemistry
    The Journal of Biological Chemistry
  • 2012
TLDR
5-Hydroxytryptamine type 3 (5-HT3) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems and have potential for the treatment of a range of other conditions.
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References

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5-HT3 receptors are membrane ion channels
TLDR
The first recordings of currents through single ion channels activated by 5-HT3 receptors are reported, in excised membrane patches from neurons of the guinea pig submucous plexus, implying a role for 5- HT, and perhaps other amines, as a 'fast' synaptic transmitter.
On the transmitter function of 5‐hydroxytryptamine at excitatory and inhibitory monosynaptic junctions
TLDR
Two symmetrical giant neurones located in the cerebral ganglion of Aplysia californica contain 4–6 p‐mole 5‐hydroxytryptamine (5‐HT) and are able to synthesize it and Stimulation of each of these neurones evokes excitatory and inhibitory potentials in various cells of the ipsilateral buccal ganglions.
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
TLDR
The differential localization of distinct muscarinic receptor subtypes on terminals releasing the major inhibitory and excitatory transmitters of the brain could be exploited therapeutically in some movement disorders and Alzheimer disease.
5‐HT3 Receptors
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    Medicinal research reviews
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TLDR
Five-HT3 receptors have several distinguishable properties and may be defined as mediating those responses of serotonin which are mimicked by the 5-HT, selective agonist 2-methyl-5-HT’ and antagonized by MDL72222 and ICS 205-930 in nanomolar concentrations.
Three serotonin responses in cultured mouse hippocampal and striatal neurons
TLDR
Serotonin (5-HT) produced 3 different types of responses in neurons of mouse hippocampal and striatal cell cultures that were inhibitory, excitatory, and slow, which are similar to responses to dopamine, norepinephrine, and forskolin, all of which are known to activate adenylate cyclase in the CNS.
Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells
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    The Journal of general physiology
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TLDR
The results indicate that the open 5-HT3 receptor channel has an effective minimum circular pore size of 7.6 A and that ionic interactions in the channel may involve negative charges near the pore mouth.
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