5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

  title={5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala},
  author={Shunsuke Sugita and K Z Shen and R. Alan North},

5-HT3 receptors

Neuropharmacology of 5-HT3 Receptor Ligands

The present chapter reviews the beginnings of a pharmacological understanding of this receptor and the therapeutic implications of drugs which have affinity for it.

A slow excitatory postsynaptic potential mediated by 5-HT2 receptors in nucleus prepositus hypoglossi

  • D. Bobker
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
Recordings of neurons of the nucleus prepositus hypoglossi in slices of guinea pig medulla indicate that the s-EPSP is mediated by 5-HT acting upon5-HT2 receptors, providing strong support for the role of 5- HT as an excitatory neurotransmitter in the CNS.

The 5-HT3B subunit is a major determinant of serotonin-receptor function

Surprisingly, the M2 region of the 5-HT3B subunit lacks any of the structural features that are known to promote the conductance of related receptors, and will be a valuable resource for defining the molecular mechanisms of ion-channel function.

The 5-HT3 Receptor Channel: Function, Activation and Regulation

The activation of the 5-HT3R opens a cationic ion channel that depolarizes the membrane, thereby activating a rapid excitatory response in a variety of central and peripheral nervous system (CNS and PNS) preparations.



5-HT3 receptors are membrane ion channels

The first recordings of currents through single ion channels activated by 5-HT3 receptors are reported, in excised membrane patches from neurons of the guinea pig submucous plexus, implying a role for 5- HT, and perhaps other amines, as a 'fast' synaptic transmitter.

On the transmitter function of 5‐hydroxytryptamine at excitatory and inhibitory monosynaptic junctions

Two symmetrical giant neurones located in the cerebral ganglion of Aplysia californica contain 4–6 p‐mole 5‐hydroxytryptamine (5‐HT) and are able to synthesize it and Stimulation of each of these neurones evokes excitatory and inhibitory potentials in various cells of the ipsilateral buccal ganglions.

Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.

The differential localization of distinct muscarinic receptor subtypes on terminals releasing the major inhibitory and excitatory transmitters of the brain could be exploited therapeutically in some movement disorders and Alzheimer disease.

5‐HT3 Receptors

  • M. Tyers
  • Biology
    Medicinal research reviews
  • 1990
Five-HT3 receptors have several distinguishable properties and may be defined as mediating those responses of serotonin which are mimicked by the 5-HT, selective agonist 2-methyl-5-HT’ and antagonized by MDL72222 and ICS 205-930 in nanomolar concentrations.

The pharmacology and function of 5-HT3receptors

Three serotonin responses in cultured mouse hippocampal and striatal neurons

Serotonin (5-HT) produced 3 different types of responses in neurons of mouse hippocampal and striatal cell cultures that were inhibitory, excitatory, and slow, which are similar to responses to dopamine, norepinephrine, and forskolin, all of which are known to activate adenylate cyclase in the CNS.

5‐Hydroxytryptamine acts at 5‐HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones.

The depolarization of neurones in the nucleus accumbens was associated with an increase in the input resistance, and was reversed in polarity by conditioning hyperpolarization; this reversal potential was linearly related to the logarithm of the extracellular potassium concentration.