5-hydroxytryptamine actions in adipocytes: involvement of monoamine oxidase-dependent oxidation and subsequent PPARγ activation

@article{Gres20125hydroxytryptamineAI,
  title={5-hydroxytryptamine actions in adipocytes: involvement of monoamine oxidase-dependent oxidation and subsequent PPAR$\gamma$ activation},
  author={Sandra Grés and Saioa G{\'o}mez-Zorita and Ana G{\'o}mez-Ruiz and Christian Carp{\'e}n{\'e}},
  journal={Journal of Neural Transmission},
  year={2012},
  volume={120},
  pages={919-926}
}
Serotonin (5-HT) is a brain neurotransmitter instrumental for the antidepressant action of selective inhibitors of serotonin reuptake (SSRIs) while it also plays important roles in peripheral organs. Recently, the 5-HT oxidation products, 5-hydroxyindoleacetate and 5-methoxy-indoleacetate, have been shown to bind to peroxisome proliferator-activated receptor γ (PPARγ) and to enhance lipid accumulation in preadipocytes. Since we already reported that adipocytes exhibit elevated monoamine oxidase… 
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References

SHOWING 1-10 OF 26 REFERENCES
Short- and long-term insulin-like effects of monoamine oxidases and semicarbazide-sensitive amine oxidase substrates in cultured adipocytes.
TLDR
Compared with previous work, substrate activation of MAO can interact with adipocyte metabolism by mimicking diverse effects of insulin in addition to preventing tumor necrosis factor alpha-dependent responses.
Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells.
TLDR
The data reveal that amine oxidase substrates partially mimic the adipogenic effect of insulin in cultured preadipocytes, and suggest that SSAO not only represents a novel late marker of adipogenesis, but could also be directly involved in the triggering of terminal adipocyte differentiation.
5-hydroxytryptamine stimulates glucose transport in cardiomyocytes via a monoamine oxidase-dependent reaction.
TLDR
The stimulation of glucose transport by 5-HT in cardiomyocytes is not mediated by a 5-hydroxytryptamine1,5-HT2, 5- HT3 or 5-ht4 receptor, nor by an adrenergic or dopaminergic receptor, but is likely to occur through the degradation of by a monoamine oxidase and concomitant formation of H2O2.
Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells.
TLDR
The results show the existence of a dose-dependent shift of activation of distinct intracellular pathways involved in 5-HT-mediated hypertrophy of cardiac cells.
Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes.
TLDR
Results show that human adipocytes express a membrane-bound SSAO that not only readily oxidizes exogenous amines and generates H(2)O(2), but that also interplays with glucose and lipid metabolism by exerting insulin-like actions, which could bring relevant information in pathologies such as obesity or diabetes.
Role of peripheral serotonin in glucose and lipid metabolism
TLDR
Recent studies show new physiological functions of peripheral serotonin, linked to glucose and lipid metabolism, which may serve as an attractive new therapeutic target for the treatment of metabolic disorders in the near future.
High expression of monoamine oxidases in human white adipose tissue: evidence for their involvement in noradrenaline clearance.
TLDR
The concomitant expression of monoamine oxidases and of a noradrenaline transporter in human white adipocytes supports the role of the adipose tissue in the clearance of peripheral catecholamines and suggests that adipocytes should be considered as a previously unknown potential target of drugs acting on monoamine oxidationases and norad Renaline transporters.
Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes.
TLDR
Compared SSAO and monoamine oxidase expression during in vitro differentiation of human preadipocytes and in adipose and stroma-vascular fractions of human fat depots shows elevated levels of amine oxidase activities found in human adipocytes may be of potential interest for therapeutic intervention in obesity.
Dietary inhibitors of monoamine oxidase A
TLDR
Although bioavailability was variable depending on the source, a healthy diet contains amounts of quercetin that might give sufficient amounts in brain to induce, by monoamine oxidase A inhibition, a small decrease in neurotransmitter breakdown.
Alteration of amine oxidase activity in the adipose tissue of obese subjects.
TLDR
The reduced MAO and the unchanged SSAO activities found in obesity suggest that these hydrogen peroxide-generating enzymes expressed in adipocytes are probably not involved in the onset of the oxidative stress found in severe obesity and/or in its complications.
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