5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

  title={5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging},
  author={Keith E. Szulwach and Xuekun Li and Yujing Li and Chun-Xiao Song and Hao Wu and Qing Dai and Hasan A Irier and Anup K Upadhyay and Marla Gearing and Allan I. Levey and Aparna Vasanthakumar and Lucy A. Godley and Qiang Chang and Xiaodong Cheng and Chuan He and Peng Jin},
  journal={Nature Neuroscience},
DNA methylation dynamics influence brain function and are altered in neurological disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5-methylcytosine, accounts for ∼40% of modified cytosine in the brain and has been implicated in DNA methylation–related plasticity. We mapped 5-hmC genome-wide in mouse hippocampus and cerebellum at three different ages, which allowed us to assess its stability and dynamic regulation during postnatal neurodevelopment through adulthood. We… CONTINUE READING
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