5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.

@article{Correale20055fluorouracilbasedCE,
  title={5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.},
  author={Pierpaolo Correale and Maria Teresa del Vecchio and Giuseppa Di Genova and Gianni Gori Savellini and Marco La Placa and Chiara Terrosi and Marzio Vestri and Renato Urso and François A. Lemonnier and Angelo Aquino and Enzo Bonmassar and Giorgio Giorgi and Guido Francini and Maria Grazia Cusi},
  journal={Journal of the National Cancer Institute},
  year={2005},
  volume={97 19},
  pages={1437-45}
}
BACKGROUND Thymidylate synthase (TS), a key enzyme in DNA synthesis, is often overexpressed in cancer cells. Some chemotherapeutic agents, such as 5-fluorouracil (5-FU), act by inhibiting TS expression. We evaluated whether a novel 28-amino acid multiepitope peptide, TS/PP, that contains the sequences of three TS-derived epitopes with binding motifs for HLA-A(*)02.01 could induce a TS-directed cytotoxic T-lymphocyte (CTL) response with antitumor activity. METHODS TS/PP peptide immunologic… CONTINUE READING