5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction.

  title={5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction.},
  author={X. L. Sun and Mu-Shui Dai and Hua Lu},
  journal={The Journal of biological chemistry},
  volume={282 11},
5-fluorouracil (5-FU) is a widely used chemotherapeutic drug for the treatment of a variety of solid tumors. The anti-tumor activity of 5-FU has been attributed in part to its ability to induce p53-dependent cell growth arrest and apoptosis. However, the molecular mechanisms underlying p53 activation by 5-FU remain largely obscure. Here we report that 5-FU treatment leads to p53 stabilization and activation by blocking MDM2 feedback inhibition through ribosomal proteins. 5-FU treatment… CONTINUE READING


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