5-azacytosine compounds in medicinal chemistry: current stage and future perspectives.

Abstract

This review summarizes the basic milestones of the research of 5-azacytosine nucleosides chronologically from their discovery and anticancer activity identification, through to subsequent unveiling of their mechanism of action based on DNA hypomethylation and tumor-suppressor gene reactivation, to the final US FDA approval of 5-azacytidine (Vidaza(®)) and 2… (More)
DOI: 10.4155/fmc.12.36

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Cite this paper

@article{Kremerov20125azacytosineCI, title={5-azacytosine compounds in medicinal chemistry: current stage and future perspectives.}, author={Marcela Kre{\vc}merov{\'a} and Miroslav Otmar}, journal={Future medicinal chemistry}, year={2012}, volume={4 8}, pages={991-1005} }