5-aza-C-induced changes in the time of replication of the X chromosomes of Microtus agrestis are followed by non-random reversion to a late pattern of replication

@article{Jablonka19875azaCinducedCI,
  title={5-aza-C-induced changes in the time of replication of the X chromosomes of Microtus agrestis are followed by non-random reversion to a late pattern of replication},
  author={Eva Jablonka and Ruth Goitein and Karl Sperling and Howard Cedar and Menashe Marcus},
  journal={Chromosoma},
  year={1987},
  volume={95},
  pages={81-88}
}
Treatment with 5-azacytidine (5-aza-C) causes an advance in the time of replication and enhances the DNase-I sensitivity of the inactive X chromosome in Gerbillus gerbillus fibroblasts. We found that these changes were not stably inherited and upon removal of the drug the cells reverted to the original state of one active and one inactive X chromosome. In… CONTINUE READING