5- and 6-Glycosylation of Transferrin in Patients with Alzheimer's Disease

@article{Rensburg20045A6,
  title={5- and 6-Glycosylation of Transferrin in Patients with Alzheimer's Disease},
  author={Susan Janse van Rensburg and Peter Berman and Felix C. V. Potocnik and Pam MacGregor and Dinie Hon and Nico de Villiers},
  journal={Metabolic Brain Disease},
  year={2004},
  volume={19},
  pages={89-96}
}
Transferrin is a glycosylated metal-carrying serum protein. One of the biological functions of glycosylation is to regulate the life span of proteins, less glycosylation leading to a faster clearance of a protein from the circulation. In the case of transferrin, this would indirectly also influence iron homeostasis. Higher glycosylation has been demonstrated in patients with Parkinson's disease and rheumatoid arthritis. A genetic variant of transferrin, TfC2, occurs with increased frequency in… CONTINUE READING
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