5 alpha-reductase isozymes in the central nervous system.

  title={5 alpha-reductase isozymes in the central nervous system.},
  author={Angelo Poletti and Annamaria Coscarella and Paola Negri-Cesi and Alessandra Colciago and F{\'a}bio Celotti and L. Martini},
  volume={63 5-6},
The enzyme 5 alpha-reductase (5 alpha-R) activates several delta 4-3keto steroids to more potent derivatives which may also acquire new biological actions. Testosterone gives rise to the most potent natural androgen dihydrotestosterone (DHT), and progesterone to dihydroprogesterone (DHP), a precursor of the endogenous anxiolytic/anesthetic steroid tetrahydroprogesterone (THP). Two isoforms of 5 alpha-R, with a limited degree of homology, different biochemical properties and distinct tissue… CONTINUE READING


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