5-Oxo-ETE and the OXE receptor.

  title={5-Oxo-ETE and the OXE receptor.},
  author={Gail E Grant and Joshua Rokach and William S Powell},
  journal={Prostaglandins & other lipid mediators},
  volume={89 3-4},
5-Oxo-ETE is a product of the 5-lipoxygenase pathway that is formed by the oxidation of 5-HETE by 5-hydroxyeicosanoid dehydrogenase (5-HEDH). 5-HEDH is a microsomal NADP(+)-dependent enzyme that is highly selective for 5-HETE. 5-Oxo-ETE synthesis is regulated by intracellular NADP(+) levels and is dramatically increased under conditions that favor oxidation of NADPH to NADP(+) such as oxidative stress and the respiratory burst in phagocytic cells. 5-Oxo-ETE is a potent chemoattractant for… CONTINUE READING


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  • M Peters-Golden
  • N Engl J Med
  • 2007

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