5-OH-tryptophane in migraine: Clinical and neurophysiological considerations

  title={5-OH-tryptophane in migraine: Clinical and neurophysiological considerations},
  author={Amerigo Boiardi and Paolo Crenna and B. Merati and S. Negri and E. Tansini and Guido Bussone},
  journal={Journal of Neurology},
SummaryThe clinical effects of the protracted treatment with 5-OH Tryptophane (5-HTP) of some patients with chronic migraine are compared with other patients treated with acetylsalicylic acid.The pain threshold was neurophysiologically determined in migraneous patients whose response to 5-HTP therapy was specially good.The results with 5-HTP can be accounted for by an action of the substance on the serotonin turnover with activation of the serotoninergic antinociceptive system… Expand
5 Citations
Safety of 5-hydroxy-L-tryptophan.
Extensive analyses of several sources of 5-HTP have shown no toxic contaminants similar to those associated with L-Trp, nor the presence of any other significant impurities, which has raised undue speculations concerning its chemistry and toxicity. Expand
Pain relief by dietary manipulation and tryptophan supplements.
The results appear to confirm that dietary manipulations are capable of altering central pain states, however, the systemic effects of long-term therapy remain to be investigated. Expand
PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva
A circadian rhythm component was built in the PK/PD model of the 5‐HTP challenge test which could better improve the understanding of the stimulating effect on HPA with cortisol change. Expand
Migraine Headache


5-Hydroxytryptamine supersensitivity as a new theory of headache and central pain: A clinical pharmacological approach with p-chlorophenylalanine
The pain from serotonin depletion may represent a chemical approach to the mechanism of central pain, such as thalamic syndrome, and may give a new suggestive light to the serotonin interpretation of migraine and some daily headaches. Expand
This theory may be considered as an evolution of the "serotonin" pathogenesis (Sicuteri 1960) since the possibility of an enhancement of the receptor sensitivity on which 5-hydroxytryptamine (5-HT) usually works is stressed. Expand
Morphine abstinence and serotonin supersensitivity in man: Analogies with the mechanism of migraine?
Venous monoamine supersensitivity in morphine abstinence, similar to that observed during migraine attacks, could be indirect evidence of an analogous mechanism in both conditions. Expand
Peripheral serotonin antagonists: Failure to antagonize serotonin in brain areas receiving a prominent serotonergic input
The failure of five putative antagonists to block 5-HT in any of the three areas tested that receive a heavy serotonergic input casts doubt on the assumption that any one of these compounds is a universal central 5- HT antagonist. Expand
Cerebrospinal fluid 5-hydroxyindoleacetic acid level in migrainous patients during spontaneous attacks, during headache-free periods and following treatment withl-tryptophan
La concentrazione di acido 5-idrossindolacetico nel liquor lombare di pazienti emicranici diminuisce lievemente e non significativamente durante l'attacco, mentre, in periodo intercritico, non èExpand
p-Chlorophenylalanine: a specific depletor of brain serotonin.
  • B. Koe, A. Weissman
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1966
The results suggest that p -chlorophenylalanine may effect 5HT depletion by inhibiting the biosynthesis of this monoamine, possibly by blocking tryptophan hydroxylation. Expand
Effects of acetylsalicylic acid on serum protein binding and metabolism of tryptophan in man
This work shows that it is important to take account of the drugs used in treatment before ascribing changes in tryptophan metabolism to pathological states and to overcome the difficulty of boiling urine samples in molar hydrochloric acid to hydrolyse any conjugates present. Expand
Comparative study of perceived pain and nociceptive flexion reflex in man
The purpose of this study was to compare the amplitude of the flexion reflex of the biceps femoris muscle (BF) with the intensity of the painful sensation elicited by a nociceptive stimulationExpand
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
It was concluded that focal brain stimulation in this region can induce analgesia in the absence of diffusely applied "whole brain" stimulation. Expand