5-OH-tryptophane in migraine: Clinical and neurophysiological considerations

@article{Boiardi20045OHtryptophaneIM,
  title={5-OH-tryptophane in migraine: Clinical and neurophysiological considerations},
  author={A. Boiardi and P. Crenna and B. Merati and S. Negri and E. Tansini and G. Bussone},
  journal={Journal of Neurology},
  year={2004},
  volume={225},
  pages={41-46}
}
SummaryThe clinical effects of the protracted treatment with 5-OH Tryptophane (5-HTP) of some patients with chronic migraine are compared with other patients treated with acetylsalicylic acid.The pain threshold was neurophysiologically determined in migraneous patients whose response to 5-HTP therapy was specially good.The results with 5-HTP can be accounted for by an action of the substance on the serotonin turnover with activation of the serotoninergic antinociceptive system… Expand
4 Citations
Safety of 5-hydroxy-L-tryptophan.
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Extensive analyses of several sources of 5-HTP have shown no toxic contaminants similar to those associated with L-Trp, nor the presence of any other significant impurities, which has raised undue speculations concerning its chemistry and toxicity. Expand
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The results appear to confirm that dietary manipulations are capable of altering central pain states, however, the systemic effects of long-term therapy remain to be investigated. Expand
PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva
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A circadian rhythm component was built in the PK/PD model of the 5‐HTP challenge test which could better improve the understanding of the stimulating effect on HPA with cortisol change. Expand

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