Corpus ID: 24206591

5-OH-dopa, product of and substrate for tyrosinase.

  title={5-OH-dopa, product of and substrate for tyrosinase.},
  author={Gun Agrup and Hans Rorsman and Evald Rosengren},
  journal={Acta dermato-venereologica},
  volume={62 5},
The formation of 5-OH-dopa on incubation of tyrosine or dopa with mushroom tyrosinase was studied. Dopa oxidase activity was defined by measuring the formation of 5-S- and 2-S-cysteinyldopa from dopa in the presence of excess amounts of cysteine. This procedure quantitating the immediate nucleophilic reaction products of dopaquinone constitutes a new method for assessing tyrosinase activity. The rate of 5-OH-dopa formation from dopa was similar to that of the formation of dopa from tyrosine… Expand
The other Topa: formation of 3,4,5-trihydroxyphenylalanine in peptides.
Hydroxylation of peptidyl-3,4-dihydroxyphenyl-l-alanine (Dopa) was observed during tyrosinase incubation of a decapeptide related to the mussel adhesive protein mefp1. The reaction was carried out atExpand
The mechanism of suicide-inactivation of tyrosinase: a substrate structure investigation.
An investigation of the tyrosinase-catalysed oxidation of a range of hydroxybenzenes which establish the structural requirements associated with inactivation and presents evidence for an inactivation mechanism based on catechol hydroxylation, with loss of one of the copper atoms at the active site. Expand
3,4-dihydroxyphenylethylamine, L-3,4-dihydroxyphenylalanine and 3,4,5-trihydroxyphenylalanine: Oxidation and binding to membranes. A comparative study of a neurotransmitter, a precursor and a neurotransmitter candidate in primitive nervous systems
  • Dr. M. Carlberg
  • Biology, Medicine
  • Journal of Neural Transmission / General Section JNT
  • 2005
5-OH-DOPA more easily undergo autoxidation than L-Dopa and dopamine, but its quinone form is probably less reactive with membrane proteins, and tyrosinase-mediated biosynthesis in primitive nervous systems and in the vertebrate CNS is discussed. Expand
The pigmented life of a redhead.
  • H. Rorsman
  • Biology, Medicine
  • Pigment cell research
  • 2004
The identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. Expand