5-Methylcytosine localised in mammalian constitutive heterochromatin

@article{Miller19745MethylcytosineLI,
  title={5-Methylcytosine localised in mammalian constitutive heterochromatin},
  author={Orlando J. Miller and Wolfgang Schnedl and Julian Allen and Bernard F. Erlanger},
  journal={Nature},
  year={1974},
  volume={251},
  pages={636-637}
}
DEOXY-5-METHYLCYTIDYLIC acid (5-MeC) is an almost universal, although minor component of DNA in plants and animals. It makes up 4–7% of the bases in plants1, no more than 1.5% of the bases in the mouse2 and even less in the human3. 5-MeC itself is not incorporated directly into DNA. Instead, specific deoxycytidylic acid residues in preformed DNA are methylated enzymatically by a highly specific DNA methylase, which transfers a methyl group from S-adenosyl methionine to specific sites in DNA4… CONTINUE READING

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