[5-Methoxypsoralen: bioavailability and pharmacokinetics].


The bioavailability of two galenic formulations of 5-methoxypsoralen (5-MOP) is described. A suspension in soft gelatine capsules was tested against a micronized powder in hard gelatine capsules on six volunteers, both in a dosage of 40 mg. The comparison of the AUC shows a significant better availability of the suspension (p less than or equal to 0.05). The detection limit of 5-MOP is 2 ng/ml plasma. The described analytical method is accurate and rapid--recovery near 100%--and is suitable for routine analysis. The pharmacokinetic parameters for 5-MOP are 2.3 h for the elimination half-life and 0.344 h-1 for the elimination rate constant.

Cite this paper

@article{Nitsche19825MethoxypsoralenBA, title={[5-Methoxypsoralen: bioavailability and pharmacokinetics].}, author={Volker Nitsche and Hermann Josef Mascher}, journal={Arzneimittel-Forschung}, year={1982}, volume={32 10}, pages={1338-41} }