5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit.


Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor. However, the melatonin analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces intraocular pressure (IOP) via MT(3) melatonin receptors. Therefore, the aim of this work was to test whether… (More)
DOI: 10.1111/j.1600-079X.2009.00702.x


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