5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity.

@article{Fischer20105LipoxygenaseII,
  title={5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity.},
  author={Astrid Stefanie Fischer and Julia Metzner and Svenja Steinbrink and Sandra K Ulrich and Carlo Angioni and Gerd 7 Geisslinger and Dieter Steinhilber and Thorsten Maier},
  journal={British journal of pharmacology},
  year={2010},
  volume={161 4},
  pages={936-49}
}
BACKGROUND AND PURPOSE Certain 5-lipoxygenase (5-LO) inhibitors exhibit anti-carcinogenic activities against 5-LO overexpressing tumour types and cultured tumour cells. It has been proposed therefore that 5-LO products significantly contribute to tumour cell proliferation. To date, the relationship between the inhibitory mechanisms of 5-LO inhibitors, which vary widely, and tumour cell viability has not been evaluated. This study addresses the anti-proliferative and cytotoxic potency of a… CONTINUE READING