5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.

@article{Chu20125LipoxygenaseGT,
  title={5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.},
  author={Jin Woo Chu and Phillip F. Giannopoulos and Carolina Ceballos-Diaz and Todd E Golde and Domenico Pratic{\`o}},
  journal={Annals of neurology},
  year={2012},
  volume={72 3},
  pages={
          442-54
        }
}
OBJECTIVE The 5-lipoxygenase (5LO) enzyme is upregulated in Alzheimer disease (AD), and its genetic absence reduces Aβ levels in APP mice. However, its functional role in modulating tau neuropathology remains to be elucidated. METHODS To this end, we generated triple transgenic mice (3xTg-AD) overexpressing neuronal 5LO and investigated their phenotype. RESULTS Compared with controls, 3xTg-AD mice overexpressing 5LO manifested an exacerbation of memory deficits, plaques, and tangle… CONTINUE READING
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