5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation

@inproceedings{Magi20145LipoxygenaseAC,
  title={5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation},
  author={Shigeyuki Magi and Yasushi Takemoto and Hiroki Kobayashi and Masato Kasamatsu and Takahiro Akita and Ayako Tanaka and Kei Takano and Etsu Tashiro and Yasuhiro Igarashi and Masaya Imoto},
  booktitle={Cancer science},
  year={2014}
}
Cell migration is an essential step for tumor metastasis. The small GTPase Rac1 plays an important role in cell migration. Previously, we reported that epidermal growth factor (EGF) induced two waves of Rac1 activation; namely, at 5 min and 12 h after stimulation. A second wave of EGF-induced Rac1 activation was required for EGF-induced cell migration, however, the spatiotemporal regulation of the second wave of EGF-induced Rac1 activation remains largely unclear. In this study, we found that 5… CONTINUE READING

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