5-Lipoxygenase: enzyme expression and regulation of activity.

  title={5-Lipoxygenase: enzyme expression and regulation of activity.},
  author={Dieter Steinhilber},
  journal={Pharmaceutica acta Helvetiae},
  volume={69 1},
5-Lipoxygenase catalyzes the transformation of arachidonic acid to leukotriene A4. This unstable intermediate can be converted to leukotriene B4 by LTA4-hydrolase or to leukotriene C4 by LTC4-synthase. Leukotrienes are involved in host defense reactions and play an important role in inflammatory diseases like asthma, inflammatory bowel disease and arthritis. The capability to release leukotrienes is restricted to a few cell types. Under pathophysiological conditions, leukotrienes are released… CONTINUE READING


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