5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine.

@article{Grider19985Hydroxytryptamine4RA,
  title={5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine.},
  author={John R. Grider and Amy E. Foxx-Orenstein and J G Jin},
  journal={Gastroenterology},
  year={1998},
  volume={115 2},
  pages={370-80}
}
BACKGROUND & AIMS The peristaltic reflex induced by mucosal stimuli is mediated by intrinsic sensory calcitonin gene-related peptide (CGRP) neurons activated by 5-hydroxytryptamine (5-HT) released from enterochromaffin cells. The involvement of 5-HT4 receptors was examined with selective 5-HT4 agonists. METHODS Compartmented intestinal segments were used to measure neurotransmitter release and the mechanical components of the reflex. RESULTS In human jejunal and rat and guinea pig colonic… CONTINUE READING