5-Hydroxytryptamine-sensitive [3H]imipramine binding of protein nature in the human brain. I. Characteristics.


[3H]Imipramine binding sites were characterized in the human brain by investigating the sensitivity to protease treatment, dependency on NaCl and the effects of drug inhibition. The binding was found to consist of a protease sensitive and a protease resistant fraction. These two fractions could be discriminated by 5-hydroxytryptamine (5-HT) but not… (More)