5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin.

  title={5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin.},
  author={Sarwat Fatima and Xiaoke Shi and Zesi Lin and Guo-qing Chen and Xiao-hua Pan and Justin Che-Yuen Wu and John Wing Shing Ho and Nikki P.Y. Lee and Heng-jun Gao and Ge Zhang and Aiping Lu and Z X Bian},
  journal={Molecular oncology},
  volume={10 2},
5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling is highly dysregulated in a majority of HCC, this study explored the regulation of Wnt/β-catenin signalling by 5-HT. The expression of various 5-HT receptors was studied by quantitative real-time polymerase chain reaction (qPCR) in HCC cell lines as… CONTINUE READING


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