5-Hydroxytryptamine-induced sensitization and activation of peripheral fibres in the neonatal rat are mediated via different 5-hydroxytryptamine-receptors

  title={5-Hydroxytryptamine-induced sensitization and activation of peripheral fibres in the neonatal rat are mediated via different 5-hydroxytryptamine-receptors},
  author={Alain Rueff and Andy Dray},
  • A. RueffA. Dray
  • Published 1 October 1992
  • Biology, Chemistry, Computer Science
  • Neuroscience

The different roles of 5-HT(2) and 5-HT(3) receptors on antinociceptive effect of paroxetine in chemical stimuli in mice.

The results indicate that the antinociceptive effect of paroxetine mainly depends on central opioidergic and serotonergic mechanisms, especially by 5-HT(3)-receptor subtypes.

Role of Serotonin Receptors in Inflammatory Pain

Experiments from the laboratory suggest that peripheral activation, by selective subtype receptor agonists, of 5-HT1 receptors induces antinociception and selective antagonists of each receptor dosedependently block this effect.

Mast Cell Degranulation Induces Delayed Rectal Allodynia in Rats: Role of Histamine and 5-HT

Mast cell degranulation initiates a delayed somatic and visceral allodynia, with the participation of serotonin, through5-HT1A receptor activation, on the visceral response.



Actions of capsaicin on peripheral nociceptors of the neonatal rat spinal cord‐tail in vitro: dependence of extracellular ions and independence of second messengers

The hypothesis that capsaicin‐induced activation, desensitization and impairment of peripheral nociceptor function is mediated by separate mechanisms is tested by use of an in vitro preparation of the neonatal rat spinal cord with the functionally attached tail.

Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture

Bradykinin activated polyphosphoinositidase C in the dorsal root ganglion neurons, elevating levels of inositol(1,4,5)-trisphosphate and 1,2- diacylglycerol, an endogenous activator of PKC, and it is suggested that PKC may mediate some of the effects of bradykin in sensory neurons.

The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

Endogenous 5‐HT appears not to play a crucial role in sensitization of high threshold mechanoreceptors in this model of chronic inflammation and arthritis, although its local release may potentiate the actions of other inflammatory mediators on sensory receptors in the ankle joint.

Selective Agonists and Antagonists at 5-Hydroxytryptamine Receptor Subtypes

This work provides an update on the pharmacological properties of some of the more commonly used agonists and antagonists at 5-HT receptors, in an attempt to identify those compounds, or combinations of compounds, which can be reliably used for the characterization of 5- HT receptors.

5-Hydroxytryptamine in burns.

  • S. Johansson
  • Biology, Medicine
    Acta physiologica Scandinavica
  • 1960
In five human patients with severe burns an increase of the urinary excretion of the 5-HT metabolite, 5-hydroxyindole-acetic acid (5-HIAA) was found, which seems to indicate an increase in the endogen metabolism of 5- HT.

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.

Results indicate that bradykinin is a physiologic mediator of pain and that bradaykinin antagonists have analgesic activity in both acute and chronic pain models.